Central line-associated blood stream infections (CLABs) are responsible for 20 to 40% of healthcare-associated blood stream infections. Risks for occurrence differ amongst clinical units dependent on the type of line used and patient intrinsic factors. A significant proportion of CLAB events are preventable through adoption of best clinical practice. The occurrence of healthcare-associated blood-stream infections (BSIs) can be used as a measure of the safety of key clinical practice processes within a unit.
As absolute rates of central line-associated infections are in general quite low, it is important for units to realize that unless the line-day denominator for the surveillance period is large, the standard error of an individual rate measurement is high. Suspected infection trends within a unit should therefore be carefully examined by appropriate statistical measures such as process control charts and other quality improvement tools to evaluate significance, at time intervals also determined by statistical considerations.
Timely investigation of significantly higher than expected numbers of events or in larger units, rates of infection, may identify system issues relating to preventative factors for documentation and corrective action.