Surgeries in pediatric patients, because of their smaller anatomy, can be technically more complex and can carry a high risk of accidental puncture or laceration (e.g., 2.22 per 1,000 discharges at 0 to 17 years, 1.84 at 18 to 44 years, 2.82 at 45 to 64 years, and 3.47 at 65 or more years). This indicator was investigated by two groups, although the definition differed slightly from the definition proposed for this measure. Miller and colleagues analyzed Healthcare Cost and Utilization Project (HCUP) data in 2000, using a publicly released version of this indicator applied to a pediatric population, and found a significant incidence of accidental puncture or laceration in pediatric patients (1.0 per 1,000 in 2000 among 0 to 18 year old children). Additionally, Miller & Zhan found that this error resulted in increased mean length of stay (by 7.7 days) and charges per stay ($41,204 on average) in affected patients, with 2.7 times higher odds of in-hospital mortality (after adjusting for age, gender, expected payer, up to 30 comorbidities, and multiple hospital characteristics, including ownership, teaching status, nursing expertise, urban location, bed size, pediatric volume, coding intensity, intensive care unit (ICU) bed percentage, and surgical discharge percentage). Sedman et al. found observed rates varying from 1.7 per 1,000 in 1999 to 1.9 per 1,000 in 2002 in the National Association of Children's Hospitals and Related Institutions (NACHRI) database (i.e., a slight upward trend over time), when applying the publicly released Agency for Healthcare Research and Quality (AHRQ) Quality Indicator (QI) definition to a pediatric population.